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Summary Brief Abstract Citation MEDLINE ASN.1 XML/SGML LinkOut Related Articles Protein Links Nucleotide Links Popset Links Structure Links Genome Links OMIM Links Eur J Clin Invest 1995 Aug;25(8):619-26

The effect of starvation on leucine, alanine and glucose metabolism in obese subjects.

Umpleby AM, Scobie IN, Boroujerdi MA, Sonksen PH epartment of Endocrinology, UMDS, London, UK. he relationship between changes in ketone concentrations and leucine  etabolism (seven obese subjects), glucose and alanine metabolism (seven  bese subjects) was investigated using radioisotopic techniques after 12  , 60 h and 2 weeks starvation. Leucine metabolism was also measured in  live lean subjects after 12 h and 60 h starvation. In the obese subjects  leucine concentration increased after 60 h starvation and leucine metabolic clearance rate, glucose and alanine concentration decreased (P < 0.05). Glucose and alanine production rate (Ra) decreased after 2 weeks (P < 0.05) but there was no change in leucine Ra after 60 h or 2 weeks. In the lean subjects leucine concentration, production rate and oxidation rate were increased after 60 h (P < 0.005, P < 0.05, P < 0.05). Ketone concentration was inversely related to alanine Ra (r = -0.51, P < 0.02) but was not related to measurements of protein metabolism in the obese subjects. This study demonstrates that the effect of short-term starvation on protein metabolism differs in lean and obese subjects. The decrease in glucose Ra during long-term starvation may be in part due to a decreased supply of alanine for gluconeogenesis.

PMID: 7589020, UI: 96047079

Summary Brief Abstract Citation MEDLINE ASN.1 XML/SGML LinkOut Related Articles Protein Links Nucleotide Links Popset Links Structure Links Genome Links OMIM Links  

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