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Summary Brief Abstract Citation
MEDLINE ASN.1 XML/SGML LinkOut Related Articles Protein Links Nucleotide Links Popset
Links Structure Links Genome Links OMIM Links Eur J Clin Invest 1995 Aug;25(8):619-26
The effect of starvation on leucine,
alanine and glucose metabolism in obese subjects.
Umpleby AM, Scobie IN, Boroujerdi
MA, Sonksen PH epartment of Endocrinology, UMDS, London, UK. he relationship between
changes in ketone concentrations and leucine etabolism
(seven obese subjects), glucose and alanine metabolism (seven bese subjects) was investigated using
radioisotopic techniques after 12 , 60 h and
2 weeks starvation. Leucine metabolism was also measured in live lean subjects after 12 h and 60 h starvation.
In the obese subjects leucine concentration
increased after 60 h starvation and leucine metabolic clearance rate, glucose and alanine
concentration decreased (P < 0.05). Glucose and alanine production rate (Ra) decreased
after 2 weeks (P < 0.05) but there was no change in leucine Ra after 60 h or 2 weeks.
In the lean subjects leucine concentration, production rate and oxidation rate were
increased after 60 h (P < 0.005, P < 0.05, P < 0.05). Ketone concentration was
inversely related to alanine Ra (r = -0.51, P < 0.02) but was not related to
measurements of protein metabolism in the obese subjects. This study demonstrates that the
effect of short-term starvation on protein metabolism differs in lean and obese subjects.
The decrease in glucose Ra during long-term starvation may be in part due to a decreased
supply of alanine for gluconeogenesis.
PMID: 7589020, UI: 96047079
Summary Brief Abstract Citation
MEDLINE ASN.1 XML/SGML LinkOut Related Articles Protein Links Nucleotide Links Popset
Links Structure Links Genome Links OMIM Links
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